Comparison of Clinical Outcomes of Coronavac Vaccinated and Unvaccinated Older Adults with Hospitalized Covid-19

Introduction: We aimed to compare the COVID-19 outcomes in unvaccinated and CoronaVac vaccinated older adults. Material(s) and Method(s): In this single-center study, patients aged >=65 years who were hospitalized for COVID-19 were retrospectively analyzed in two groups: unvaccinated and vaccinated. Result(s): A total of 742 patients were included. The mean age was 76.6+/-7.6 years. Of these, 46.1% (n=342) were male, 76.0% (n=564) were vaccinated. Among patients who were transferred to the intensive care unit (n=217), 206 (27.8%) received invasive mechanical ventilation support and 194 (26.1%) were died. In the multivariate analysis, advanced age (OR=1.03, 95%CI=1.01-1.06, p<0.01) and a high Charlson Comorbidity Index (OR=1.24, 95%CI=1.12-1.38, p<0.01) were predictors of mortality, while being vaccinated (OR=0.75, 95%CI=0.62-0.91, p<0.01) was associated with survival. Vaccination reduced the need for intensive care by 26.5% and mortality by 24.9 %. When the vaccinated group was evaluated, high Charlson Comorbidity Index (OR=1.428, 95%CI=1.14-1.64, p<0.01) was an independent predictor for mortality. However, booster vaccination in the last 130 days was the only protective factor that reduced mortality (p=0.04, 95%CI=0.43-0.99, OR=0.66) in multivariate analysis. Booster dose vaccination in the last 130 days reduced mortality by 33.8%. Conclusion(s): CoronaVac vaccination improved survival in hospitalized older adult patients (>=65 years old) with COVID-19. However, delaying the booster dose for more than 130 days were significantly associated with decreased survival. Therefore, older adults who completed their primary vaccination series with CoronaVac should not delay their booster dose to reduce the risk of death. Copyright © 2022, Geriatrics Society. All rights reserved.

The prognostic role of D-dimer in hospitalized COVID-19 patients.

INTRODUCTION: In COVID-19 patients, the determination of the relationship between elevated D-dimer level and prognosis and the determination of thrombosis formation in the early stages of the disease are very important. The aim of this study was to investigate the prognostic role of D-dimer levels based on presentation in patients hospitalized with the diagnosis of COVID-19. METHOD: The study was conducted on patients hospitalized with the diagnosis of laboratory-confirmed COVID-19 between March 11 and April 20, 2020. Patients with diseases that could have caused an increase in D-dimer were excluded from the study. RESULTS: The evaluation was made across a total of 1,669 patients, comprising 782 (46.9 %) females and 887 (53.1 %) males. The effects of D-dimer, CRP, ferritin, and troponin on mortality were evaluated with Enter Logistic Regression Analysis, and the model was found to be significant, with an explanatory coefficient of the model at a very good level of 91.3 %. The D-dimer scores were determined to be higher in patients who did not survive. The risk of mortality was seen to be 7.325-fold higher in cases with D-dimer measurement ≥0.5. CONCLUSION: The study results showed that the D-dimer test was an independent risk factor showing mortality in COVID-19 patients (Tab. 6, Ref. 27). Text in PDF www.elis.sk Keywords: D-dimer, SARS-CoV-2, mortality.

The importance of healthcare workers to comply with infection prevention and control instructions during COVID-19 outbreak-a survey study. (Special Issue: COVID-19;experiences and future prospects part II.)

Objective: Taking precations to prevent contamination and developing prevention programs play a key role in the outbreak. For this purpose, the use of personal protective equipment (PPE) of healthcare workers (HCWs) and their compliance with hand hygiene were investigated in the current Coronavirus disease-19 (COVID-19) outbreak.